|
Symbol Name ID |
Raf1
v-raf-leukemia viral oncogene 1 MGI:97847 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Bruising susceptibility |
Abnormal cardiovascular system morphology |
Atrial septal defect |
Abnormal pulmonary valve morphology |
Dilated cardiomyopathy |
Hypertrophic cardiomyopathy |
Coarctation of aorta |
Pulmonary artery stenosis |
Patent ductus arteriosus |
Reduced left ventricular ejection fraction |
Increased left ventricular end-diastolic volume |
Mitral regurgitation |
Pulmonic stenosis |
Abnormal EKG |
Abnormal ST segment |
Arrhythmia |
Ventricular arrhythmia |
Congestive heart failure |
Abnormality of the lymphatic system |
Abnormality of the spleen |
| Disease(s) Associated with RAF1 | ||||||||||||||||||||
| dilated cardiomyopathy 1NN | ||||||||||||||||||||
| Noonan syndrome | ||||||||||||||||||||
| Noonan syndrome 5 | ||||||||||||||||||||
| Noonan syndrome with multiple lentigines 2 |
| Mouse Phenotypes | cardiovascular system phenotype |
abnormal liver sinusoid morphology |
abnormal placental labyrinth vasculature morphology |
abnormal vasculogenesis |
absent vitelline blood vessels |
increased myocardial fiber size |
thin myocardium |
increased heart right atrium size |
thick interventricular septum |
increased heart weight |
enlarged heart |
cardiac hypertrophy |
abnormal heart left ventricle morphology |
increased heart left ventricle size |
dilated heart left ventricle |
increased heart ventricle size |
thick ventricular wall |
distended pericardium |
cardiac fibrosis |
cardiac interstitial fibrosis |
dilated cardiomyopathy |
abnormal cardiovascular system physiology |
increased cardiac output |
increased cardiac stroke volume |
hemorrhage |
decreased cardiac muscle contractility |
decreased ventricle muscle contractility |
increased cardiac muscle contractility |
abnormal heart left ventricle pressure |
increased left ventricle systolic pressure |
increased cardiomyocyte apoptosis |
increased response of heart to induced stress |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||
| Raf1tm1Bacc/Raf1tm1Bacc | |||||||||||||||||||||||||||||||||
| Raf1tm1Ulb/Raf1tm1Ulb | |||||||||||||||||||||||||||||||||
| Raf1tm1Zim/Raf1tm1Zim | |||||||||||||||||||||||||||||||||
| Raf1tm2.1Ara/Raf1tm2.1Ara | |||||||||||||||||||||||||||||||||
| Raf1tm1.1Bgn/Raf1+ | * | ||||||||||||||||||||||||||||||||
| Raf1tm2Bacc/Raf1tm2Bacc Tg(Myh6-cre)2182Mds/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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